Jaguars HC Liam Coen addresses the locker room after a 26-21 win over the San Francisco 49ers in Week 4 of the 2025 NFL Season.

The Jaguars strung together another physical performance in a 26-21 victory over the 49ers, highlighted by a stout rushing attack and a defense that continues to stack takeaways.

Jaguars HC Liam Coen speaks with the media after a 26-21 win against the San Francisco 49ers in Week 4 of the 2025 NFL Season.

Watch the Jacksonville Jaguars' top plays vs. the San Francisco 49ers in Week 4 of the 2025 NFL season.

Watch the best plays from Jaguars RB Travis Etienne Jr.'s 124-yard game against the San Francisco 49ers in Week 4 of the 2025 NFL season.

Watch highlights from the Week 4 matchup between the Jacksonville Jaguars and the San Francisco 49ers during the 2025 NFL season.

DT Arik Armstead knocks the ball loose from 49ers' QB Brock Purdy and is recovered for a turnover that gives the Jaguars the win.

RB Travis Etienne Jr. sneaks through the 49ers defense for an 11-yard rush.

K Cam Little splits the uprights for a 44-yard field goal midway through the third quarter.

WR Parker Washington fields a punt and somehow returns it all way to the end zone to put the Jaguars back up by two scores.

LB Devin Lloyd intercepts 49ers' QB Brock Purdy's pass for his second of the game.

RB Travis Etienne Jr. slips though the 49ers defense for an 18-yard rush.

K Cam Little cashes in a short field goal to pad the Jaguars' lead right before the end of the first half.

RB Bhayshul Tuten sets the Jaguars up with great field position right before halftime with a 54-yard return.

QB Trevor Lawrence finds TE Hunter Long in the flat for a 4-yard touchdown.

WR/DB Travis Hunter bounces up to grab a 28-yard dot from QB Trevor Lawrence on third-and-15.

Devin Lloyd intercepts Brock Purdy's pass off of a tip to set the Jaguars up with good field position.

RB Travis Etienne Jr. breaks away for a 48-yard touchdown run midway through the second quarter.

LB Dennis Gardeck punches the ball out of 49ers' TE Luke Farrell's grasp for an early game turnover.

QB Trevor Lawrence slings a 14-yard pass to WR Brian Thomas Jr. for a first down.

Jaguars Team Reporter Kainani Stevens catches up with RB Bhayshul Tuten after practice. Get to know more about the rookie on Off the Field, presented by Dream Finders Homes.

Jaguars HC Liam Coen speaks to the media on Friday of Week 4 during the 2025 NFL Season.

Jaguars GM James Gladstone and Executive VP of Football Operations Tony Boselli review team performance so far this season and share insight on the upcoming matchup against the 49ers on this episode of Jags HQ, presented by Fresh from Florida.

J.P. Shadrick, Jeff Lageman and former Jaguars LB coach Mark Duffner dive into the matchup against the 49ers on Jaguars Happy Hour, presented by Heritage Roofing. The crew preview the matchups on both sides of the ball and weigh in on how the Jaguars will fare on Sunday.

Jaguars Linebacker Devin Lloyd joins Senior Writer John Oehser for the O-Zone Podcast as he prepares for Week 4 against the Texans. Lloyd discusses getting into better shape this offseason, playing for Defensive Coordinator Anthony Campanile and the Jaguars early defensive success in 2025. All this and more on The O-Zone Podcast.