LB Devin Lloyd intercepts 49ers' QB Brock Purdy's pass for his second of the game.

Watch the Jacksonville Jaguars' top plays vs. the San Francisco 49ers in Week 4 of the 2025 NFL season.

Watch the best plays from Jaguars RB Travis Etienne Jr.'s 124-yard game against the San Francisco 49ers in Week 4 of the 2025 NFL season.

Watch highlights from the Week 4 matchup between the Jacksonville Jaguars and the San Francisco 49ers during the 2025 NFL season.

DT Arik Armstead knocks the ball loose from 49ers' QB Brock Purdy and is recovered for a turnover that gives the Jaguars the win.

RB Travis Etienne Jr. sneaks through the 49ers defense for an 11-yard rush.

K Cam Little splits the uprights for a 44-yard field goal midway through the third quarter.

WR Parker Washington fields a punt and somehow returns it all way to the end zone to put the Jaguars back up by two scores.

RB Travis Etienne Jr. slips though the 49ers defense for an 18-yard rush.

K Cam Little cashes in a short field goal to pad the Jaguars' lead right before the end of the first half.

RB Bhayshul Tuten sets the Jaguars up with great field position right before halftime with a 54-yard return.

QB Trevor Lawrence finds TE Hunter Long in the flat for a 4-yard touchdown.

WR/DB Travis Hunter bounces up to grab a 28-yard dot from QB Trevor Lawrence on third-and-15.

Devin Lloyd intercepts Brock Purdy's pass off of a tip to set the Jaguars up with good field position.

RB Travis Etienne Jr. breaks away for a 48-yard touchdown run midway through the second quarter.

LB Dennis Gardeck punches the ball out of 49ers' TE Luke Farrell's grasp for an early game turnover.

QB Trevor Lawrence slings a 14-yard pass to WR Brian Thomas Jr. for a first down.

Jeff Lageman rolls the tape on Week 3 and breaks down three plays that demonstrate players on both sides of the ball showing resilience and determination at the end of the game and how that contributed to a big win against the Texans. Check it out on Film Room, powered by Microsoft Copilot+PC.

Watch the Jacksonville Jaguars' top plays vs. the Houston Texans in Week 3 of the 2025 NFL season.

Watch highlights from the Week 3 matchup between the Houston Texans and the Jacksonville Jaguars during the 2025 NFL season.

S Antonio Johnson picks off Texans' QB C.J. Stroud on their final drive to seal the win in Week 3.

RB Travis Etienne Jr. bursts into the end zone for a game-winning 10-yard touchdown run.

Brian Thomas Jr. escapes from the Texans' secondary across the field for 46 yards to set the Jaguars up on the 10-yard line.

QB Trevor Lawrence escapes the pocket and runs for 10 yards and a first down to extend the Jaguars' drive.

CB Tyson Campbell strips the ball from Texans' WR Nico Collins which is then recovered by LB Devin Lloyd to set the Jaguars up with the ball.