QB Trevor Lawrence finds TE Brenton Strange who takes the ball 22 yards downfield into Chiefs territory.

K Cam Little nails a 52-yard field goal midway through the 4th quarter to give the Jaguars a late lead.

LB Devin Lloyd picks off Chiefs' QB Patrick Mahomes and takes it 99 yards to the house to put the Jaguars up by 6.

Trevor Lawrence slides out of the pocket and into the end zone for a 10-yard touchdown.

QB Trevor Lawrence hurls the ball downfield to WR/DB Travis Hunter who goes up over two defenders for a 44-yard gain.

WR/DB Travis Hunter stutter steps to evade tackle for 12-yard catch and run.

WR Parker Washington catches a 3-yard touchdown in the corner of the end zone to cut the Chiefs lead to one score.

QB Trevor Lawrence dots a 22-yard pass across the middle to WR Brian Thomas Jr.

Jeff Lageman rolls the tape on Week 4 and breaks down two big Travis Etienne runs and shows how the tough blocking performance helped the Jaguars get the win against the 49ers. Check it out on Film Room, powered by Microsoft Copilot+PC.

Watch the Jacksonville Jaguars' top plays vs. the San Francisco 49ers in Week 4 of the 2025 NFL season.

Watch the best plays from Jaguars RB Travis Etienne Jr.'s 124-yard game against the San Francisco 49ers in Week 4 of the 2025 NFL season.

Watch highlights from the Week 4 matchup between the Jacksonville Jaguars and the San Francisco 49ers during the 2025 NFL season.

DT Arik Armstead knocks the ball loose from 49ers' QB Brock Purdy and is recovered for a turnover that gives the Jaguars the win.

RB Travis Etienne Jr. sneaks through the 49ers defense for an 11-yard rush.

K Cam Little splits the uprights for a 44-yard field goal midway through the third quarter.

WR Parker Washington fields a punt and somehow returns it all way to the end zone to put the Jaguars back up by two scores.

LB Devin Lloyd intercepts 49ers' QB Brock Purdy's pass for his second of the game.

RB Travis Etienne Jr. slips though the 49ers defense for an 18-yard rush.

K Cam Little cashes in a short field goal to pad the Jaguars' lead right before the end of the first half.

RB Bhayshul Tuten sets the Jaguars up with great field position right before halftime with a 54-yard return.

QB Trevor Lawrence finds TE Hunter Long in the flat for a 4-yard touchdown.

WR/DB Travis Hunter bounces up to grab a 28-yard dot from QB Trevor Lawrence on third-and-15.

Devin Lloyd intercepts Brock Purdy's pass off of a tip to set the Jaguars up with good field position.

RB Travis Etienne Jr. breaks away for a 48-yard touchdown run midway through the second quarter.

LB Dennis Gardeck punches the ball out of 49ers' TE Luke Farrell's grasp for an early game turnover.