We have long since known London was calling the Jaguars.

Now, we know the first traveling partner.

The Jaguars, the first NFL team to commit to playing a series of games overseas, will play host to the San Francisco 49ers at London's historic Wembley Stadium on Sunday, October 27, 2013, the NFL announced Thursday.

The game will kick off at 1 p.m. ET, which is 5 p.m. in the United Kingdom.

"Everyone associated with the Jacksonville Jaguars is very much looking forward to our four home games in London through 2016," Jaguars Owner Shad Khan said in a statement making the announcement on Thursday. "We're particularly thrilled and honored that our first opponent will be the San Francisco 49ers."

The game will be the first of what is scheduled to be a four-year run in London for the Jaguars. The franchise earlier this year committed to a game at Wembley in the 2013, 2014, 2015 and 2016 regular seasons.

"By committing to play a regular-season home game in London in each of the next four years, the Jaguars will play a major role in helping grow our sport in the U.K. and beyond," said NFL Commissioner Roger Goodell.  "We think Jaguars-49ers is a match-up our fans will really enjoy and a great way to start a new era in the international development of our game."

Khan confirmed the 2013 International Series opponent while speaking at a sports business conference in London.

"This is a unique and important opportunity for the Jaguars franchise, as well as for our fans and community," Khan said. "To share this stage in our first year at Wembley with a rising power like the 49ers will bring additional attention and respect to what we're trying to achieve as a franchise. 

"We can't wait to see our global vision for the Jaguars become reality next season."

San Francisco will be playing its second regular-season game in London, having beaten the Denver Broncos at Wembley, 24-16, in 2010.

 "The 49ers are excited and privileged to once again serve as ambassadors for the NFL and the game of football internationally," 49ers Chief Executive Officer Jed York said. "Our 2010 experience in London was tremendous. The atmosphere at Wembley Stadium on game day was electric.

"The ability for us to share 49ers football with our faithful fans internationally is a treat for everyone in our organization."

The Rams and Patriots will play at Wembley two weeks from Sunday, with the sellout crowd expected to be more than 80,000 people.