The Jacksonville Jaguars are set for an AFC South derby on British soil with the announcement that they are to take on the Indianapolis Colts at Wembley Stadium in the 2016 International Series.
The Jaguars will face their divisional rivals in London during week 4 of the NFL season on October 2 looking for a second win in a row at their home from home after the 34-31 thriller against the Buffalo Bills this year.
The Colts will be making their very first trip to the UK.
This will be the first AFC South fixture and only the second divisional match-up in NFL history played outside of the USA following the New York Jets 27-14 victory over the Miami Dolphins in the first International Series Game of 2015.
In the other two games the Cincinnati Bengals will play their first international game as they host the Washington Redskins at Wembley.
And at Twickenham the St Louis Rams will host one team from the NFC East based on final standings – either the Philadelphia Eagles, making their first UK trip, the Dallas Cowboys or the New York Giants.
Ticket details will be released soon so keep checking jaguars.com/uk for more information.